Francesco John DeMayo

Increased chromatin accessibility following 1α,25-dihydroxyvitamin D3 treatment in human endometrial stromal cells

This study examines how 1,25-dihydroxyvitamin D3 affects chromatin accessibility in human endometrial stromal cells using ATAC-seq, revealing increased signal intensity and pre-accessible chromatin environments for transcription.

Impact of vitamin D deficiency on defective endometrial decidualization and the repressive role of vitamin D receptor (VDR) in the epigenomic network

This study shows that vitamin D receptor (VDR) regulates endometrial decidualization by modulating chromatin accessibility and gene expression, with implications for fertility and uterine disorders.

Deciphering ESR1-driven transcription in human endometrial stromal cells via transcriptome, cistrome, and integration with chromatin landscape

This study investigates ESR1 and estrogen-driven transcription in human endometrial stromal cells using transcriptome, cistrome, and chromatin landscape data to identify gene regulation and its implications in decidualization and endometrial cancer.

Assessment of the Histone Mark-based Epigenomic Landscape in Human Myometrium at Term Pregnancy

This study maps the epigenomic landscape of human myometrium at term pregnancy, identifying enhancers and regulatory elements associated with PGR and PLCL2.

Impact of Essential Genes on the Success of Genome Editing Experiments Generating 3,313 New Genetically Engineered Mouse Lines

The paper analyzes 3,313 genetically engineered mouse lines to identify gene essentiality as the main factor affecting Cas9-based genome editing success.

The estrogen receptor α cistrome in human endometrium and epithelial organoids

The paper integrates ESR1 cistrome and transcriptome data from endometrial biopsies and organoids to identify estrogen-regulated genes and their functional roles in endometrial health.

Inserting Cre Recombinase into the Prolactin 8a2 gene for Decidua-Specific recombination in Mice

This paper develops a mouse strain with decidua-specific Cre recombinase expression to study decidualization and infertility.

A resource of targeted mutant mouse lines for 5,061 genes

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

WNK1 regulates uterine homeostasis and its ability to support pregnancy

This study identifies WNK1's role in uterine homeostasis and pregnancy by showing its regulation of AKT signaling through PP2A in endometrial cells.

Increased FOXL2 Expression Alters Uterine Structures and Functions

This study shows that increased FOXL2 expression in the female reproductive tract causes uterine structural and functional abnormalities, contributing to infertility and endometriosis progression.

Dynamic Transcriptome, Accessible Genome and PGR Cistrome Profiles in the Human Myometrium

Term-pregnant versus nonpregnant human myometrium shows 2890 differentially expressed genes, more open chromatin regions (85777 vs 45501), and progesterone receptor binding shifted from promoters toward distal sites.

Human Endometrial Transcriptome and Progesterone Receptor Cistrome Reveal Important Pathways and Epithelial Regulators

The paper identifies PGR-regulated genes and pathways in endometrium during the window of implantation using RNA-seq and PGR-ChIP-seq.

An ancient fecundability-associated polymorphism creates a new GATA2 binding site in a distal enhancer of HLA-F

The paper identifies a G/A polymorphism in rs2523393 that creates a new GATA2 binding site in an HLA-F enhancer, associated with fecundability and linked to multiple sclerosis risk.