Aharon G. Freud

The paper identifies CD200R1 as a marker for an immature NK-cell precursor in tonsils, distinguishing between oligopotent and more restricted developmental stages.

This study maps human natural killer cell development in tonsil using single-cell analysis, showing spatial trajectories and tissue niches that support NK cell differentiation.

This paper shows CDK4/6 inhibitors make breast cancer cells more susceptible to NK cell therapy by increasing surface proteins that NK cells recognize.

The paper identifies NFAT inhibition as a cause of reduced uterine natural killer (uNK) cells and pregnancy complications in humans through analysis of uterus transplant recipients.

This study identifies a developmental program in human uterine NK cells that links tissue residency with divergent effector functions through TGF-β responsive gene regulation.

The paper examines the ratio of sense and antisense transcripts of GATA1 and GATA2 in human progenitors and leukemia cell lines, showing that promoter competition influences cell fate decisions during differentiation.

RIGATonI identifies genomic alterations in tumors affecting lymphocyte infiltration using machine learning and integrates immune phenotype and function predictions.

This study identifies sequential transcriptional programs of tissue residency driving human uterine NK cell development through single-cell analyses.

The paper identifies binary promoter switches in lineage-determining transcription factors, showing mutually exclusive sense/antisense transcription and distinct gene expression patterns in different cell states.