Josep Rotllant

Evolution of CTCF underlies the establishment of loop extrusion as a predominant chromatin folding mechanism in vertebrates

The paper investigates the evolution of CTCF's role in chromatin organization across species, finding that vertebrate CTCF enables loop extrusion but requires additional factors for full genome architecture.

Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons

The paper identifies QRFP/Pth4 neurons in zebrafish hypothalamus as a novel sleep-promoting population that acts through hindbrain monoaminergic neurons.

Genetic ablation of Pth4 disrupts calcium-phosphate balance, bone development, and kidney transcriptome in teleosts

This study shows that knocking out Pth4 in zebrafish causes calcium-phosphate imbalance, skeletal issues, and changes in kidney gene expression.

alms1 regulates the immune response and brain ageing in zebrafish

This study investigates the role of alms1 in zebrafish, showing its impact on immune response and brain ageing through transcriptomic analysis and CRISPR/Cas9 depletion.

Epigenetic Regulation During Flatfish Metamorphosis: Integrative Omics Analysis of DNA Methylation and Gene Expression in Turbot Brain

This study investigates DNA methylation and gene expression changes during flatfish metamorphosis using multi-omics data from turbot brain at three stages.

Epigenetic Regulation of Visual System Remodeling During Flatfish Metamorphosis: DNA Methylation Dynamics in Ocular Migration and Visual Adaptation

This study examines DNA methylation changes in migrating and non-migrating eyes of turbot during metamorphosis, linking methylation patterns to gene expression and visual system remodeling.

The skin microbiome as a new potential biomarker in the domestication and welfare of Octopus vulgaris

This study characterizes the mucosal skin microbiome of wild and captive-bred common octopuses to assess the impact of aquaculture on animal welfare.