Author

Jonathan P. Schneck

Johns Hopkins UniversityORCID 0000-0001-5346-2776Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:mouse· 1 Assay:multiome· 1 Approach:statistical model· 1

Frequent Co-Authors

Christine Y. WeiiD· 3 shared Hai‐Quan MaoiD· 3 shared Jinghan LiniD· 3 shared Jingyao MaiD· 3 shared Kailei D. GoodieriD· 3 shared Xiang LiuiD· 3 shared Xiaoya LuiD· 3 shared Yining ZhuiD· 3 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

Christine Y. WeiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintApr 12, 2026

Engineering age-adaptive mRNA lipid nanoparticle cancer vaccines via reprogramming systemic gene expression

Yining Zhu, Christine Y. Wei, Jingyao Ma…·Hai‐Quan Mao

This paper identifies age-related impairment in systemic mRNA translation as a barrier to mRNA vaccine efficacy and develops an LNP formulation to restore transgene expression and T cell immunity in aged hosts.

DOI 10.64898/2026.04.11.717910

mousemultiome

𝕏 PostBluesky

BioengineeringbioRxivPreprintApr 21, 2025

Systemic trafficking of mRNA lipid nanoparticle vaccine following intramuscular injection generates potent tissue-specific T cell response

Christine Y. Wei, Yining Zhu, Xiaoya Lu…·Hai‐Quan Mao

This study shows that mRNA lipid nanoparticles (LNPs) can be tailored to traffic to specific organs, enhancing tissue-specific T cell responses and vaccine efficacy.

1 citation

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BioengineeringbioRxivPreprintJan 27, 2025

mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite generates a local immunostimulatory niche for cancer immunotherapy

Yining Zhu, Zhi‐Cheng Yao, S.-H. Li…·Hai‐Quan Mao

The paper develops a nanofiber-hydrogel composite incorporating mRNA lipid nanoparticles to create a local immunostimulatory niche for cancer immunotherapy, showing enhanced immune responses with a single dose.

2 citations

experimental assaycancer & tumor microenvironment

𝕏 PostBluesky