PhysiologyJournal of the American Heart AssociationPeer-reviewed
Cardiomyocyte-specific plakophilin-2 loss is sufficient to induce aging and senescence of nonmyocytes. Relevance to arrhythmogenic cardiomyopathy.
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito…·Mario Delmar
This study shows that loss of PKP2 in cardiomyocytes induces pro-inflammatory senescence in non-myocytes and premature cardiac aging, linking desmosomal arrhythmogenic cardiomyopathy to cellular senescence and aging mechanisms.
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