Adriana Heguy

Cyclin D-CDK4/6 couple proliferation to membrane and mitochondrial protein supply through a DeSI1 phospho-switch

This study identifies DeSI1 as a cyclin D-CDK4/6 substrate whose phosphorylation regulates membrane and mitochondrial protein supply during proliferation.

Cardiomyocyte-specific plakophilin-2 loss is sufficient to induce aging and senescence of nonmyocytes. Relevance to arrhythmogenic cardiomyopathy.

This study shows that loss of PKP2 in cardiomyocytes induces pro-inflammatory senescence in non-myocytes and premature cardiac aging, linking desmosomal arrhythmogenic cardiomyopathy to cellular senescence and aging mechanisms.

Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression

This study analyzes clonal heterogeneity in human pancreatic ductal adenocarcinoma using single-cell and spatial transcriptomics, revealing transcriptional continua, clonal transitions, and spatially dispersed clones associated with metastasis.

The coordination between CTCF, cohesin and TFs impacts nucleosome repositioning and chromatin insulation to define state specific 3D chromatin folding

The paper investigates how CTCF, cohesin, and TFs influence nucleosome repositioning and chromatin insulation across cell states using mouse and human data.

Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma

This study identifies inflammation in tumor-adjacent lung tissue as a predictor of clinical outcome in lung adenocarcinoma using multi-omic analysis of 143 stage I cases.

De novo assembly and annotation of the singing mouse genome

The paper assembles and annotates the genome of the singing mouse, using single nuclei sequencing to identify cell types in a brain region involved in song coordination.

Integrative Multi-omic Profiling of Two Human Decedents Receiving Pig Heart Xenografts Reveals Strong Perturbations in Early Immune-Cell and Cellular Metabolism Responses.

The paper analyzes multi-omic data from two pig heart xenografts in human decedents to identify immune and metabolic responses associated with rejection and injury.

iCellR: Combined Coverage Correction and Principal Component Alignment for Batch Alignment in Single-Cell Sequencing Analysis

The paper introduces two batch alignment methods for single-cell RNA sequencing to address drop-out issues and improve clustering accuracy across batches.

Experimental analysis of exome-scale mutational signature of glycidamide, the reactive metabolite of acrylamide

The paper identifies a unique mutational signature of glycidamide, a metabolite of acrylamide, through experimental and computational analysis, linking it to cancer genome patterns.

The translatome of adult cortical axons is regulated by learning in vivo

The paper shows that learning regulates protein synthesis in adult rat amygdala axons, identified through TRAP-RNASeq, revealing upregulated mitochondrial and translation-related genes and downregulated synaptic genes.