Gyles Ward

Cyclin D-CDK4/6 couple proliferation to membrane and mitochondrial protein supply through a DeSI1 phospho-switch

This study identifies DeSI1 as a cyclin D-CDK4/6 substrate whose phosphorylation regulates membrane and mitochondrial protein supply during proliferation.

Cardiomyocyte-specific plakophilin-2 loss is sufficient to induce aging and senescence of nonmyocytes. Relevance to arrhythmogenic cardiomyopathy.

This study shows that loss of PKP2 in cardiomyocytes induces pro-inflammatory senescence in non-myocytes and premature cardiac aging, linking desmosomal arrhythmogenic cardiomyopathy to cellular senescence and aging mechanisms.

Population analysis and immunologic landscape of melanoma in people living with HIV indicate impaired antitumor immunity

This paper analyzes melanoma in people living with HIV, finding impaired antitumor immunity, delayed ICI treatment, and an immunosuppressive tumor microenvironment.