TNFa hinders FGF4 efficacy to mitigate ALS astrocyte dysfunction and cGAS-STING pathway-induced innate immune reactivity
Erika Velásquez, Ekaterina Savchenko, Sara Marmolejo-Martínez-Artesero, Désiré Challuau, Aline Aebi, Yuriy Pomeshchik, Nuno Jorge Lamas, Mauno Vihinen, Melinda Rezeli, Bernard Laurent Schneider, Cédric Raoul, Laurent Roybon
This study shows that FGF4 reduces ALS astrocyte reactivity but fails to protect motor neurons in a mouse model, while TNF exacerbates astrocyte dysfunction.
bioRxiv · Nov 8, 2023 · PreprintNeuroscience