NeurosciencebioRxivPreprint
TNFa hinders FGF4 efficacy to mitigate ALS astrocyte dysfunction and cGAS-STING pathway-induced innate immune reactivity
Erika Velásquez, Ekaterina Savchenko, Sara Marmolejo-Martínez-Artesero…·Laurent Roybon
This study shows that FGF4 reduces ALS astrocyte reactivity but fails to protect motor neurons in a mouse model, while TNF exacerbates astrocyte dysfunction.
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