Patrick Laurent

This study shows that lipocalin LPR-1 and scavenger receptor SCAV-2 have opposing roles in maintaining the apical extracellular matrix of narrow tubes in C. elegans.

The paper profiles single-cell RNA sequencing data from sex-shared neurons in C. elegans to reveal molecular dimorphism and sex-biased gene expression patterns.

This study identifies how sensory stimuli and ciliary trafficking defects trigger the release of ciliary extracellular vesicles from different ciliary regions in C. elegans.

The paper identifies PHAC-1 as a regulator of synaptic transmission in C. elegans and shows that DEE70 variants disrupt cholinergic signalling at the neuromuscular junction.

The paper uses multidimensional phenotyping of C. elegans to predict lifespan and quantify health, showing that more features improve prediction accuracy.

The paper combines scRNA-seq with a molecular atlas to identify new neuron class markers in C. elegans, assigning 58 clusters to known neuron classes and validating 15 new promoters.

This study uses multi-parametric phenotyping to analyze ageing trajectories in C. elegans, revealing divergent ageing patterns in disease models and quantifying health states through phenotypic flexibility.