Omer Acar

This study evaluates Ancestral Sequence Reconstruction (ASR) as a tool to detect de novo genes by analyzing ~2,600 yeast genes and identifying 33 de novo emerged genes.

The paper identifies a large noncanonical translatome in yeast, showing most translated elements are not conserved genes and contribute to phenotype through fast-evolving mechanisms.

The paper develops a coexpression analysis framework to study noncanonical open reading frames (nORFs) in yeast, revealing their transcriptional regulation, evolutionary patterns, and cellular roles.

The paper uses elastic network modeling to identify sensor and effector genes in yeast that control information flow through long-range interactions.