Author

Lin Chou

University of PittsburghORCID 0000-0002-0227-5521Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Approach:statistical model· 2 Organism:yeast· 2 Organism:bacteria (other)· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Aaron C. WacholderiD· 2 shared Anne‐Ruxandra CarvunisiD· 2 shared Carly J. HoughtoniD· 2 shared Nelson Castilho CoelhoiD· 2 shared Saurin Bipin ParikhiD· 2 shared Alexandra J. WeisbergiD· 1 shared Catherine A. DoudsiD· 1 shared Chih‐Feng WuiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersEvolutionary Biology

Aaron C. WacholderORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintSep 1, 2026

Environmental stress and phenotypic tradeoff modulate the adaptive potential of novel coding sequences for de novo gene birth

Lin Chou, Nelson Castilho Coelho, Saurin Bipin Parikh…·Anne‐Ruxandra Carvunis

The paper shows that environmental stress influences the phenotypic impact of de novo ORFs, with tradeoffs and stress-dependent growth effects observed in yeast.

DOI 10.64898/2026.08.24.746591

yeastproteomics

𝕏 PostBluesky

GenomicsCell SystemsPeer-reviewedMay 1, 2023

A vast evolutionarily transient translatome contributes to phenotype and fitness

Aaron C. Wacholder, Saurin Bipin Parikh, Nelson Castilho Coelho…·Anne‐Ruxandra Carvunis

The paper identifies a large noncanonical translatome in yeast, showing most translated elements are not conserved genes and contribute to phenotype through fast-evolving mechanisms.

66 citationstop 2%

yeastproteomics

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GenomicsBMC BiologyPeer-reviewedJan 12, 2022

Modular evolution of secretion systems and virulence plasmids in a bacterial species complex

Lin Chou, Yu-Chen Lin, Mindia Haryono…·Chih‐Horng Kuo

The paper analyzes genome diversity in Agrobacterium tumefaciens to study the evolution of secretion systems and virulence plasmids, revealing gene losses, horizontal transfers, and modularity in molecular evolution.

27 citations

bacteria (other)whole-genome sequencing

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