Carly J. Houghton

The paper shows that environmental stress influences the phenotypic impact of de novo ORFs, with tradeoffs and stress-dependent growth effects observed in yeast.

This study investigates how de novo proteins in yeast integrate into cellular systems using ancient targeting and degradation pathways, revealing a conserved molecular signature that enables their ER localization and regulation.

The paper identifies a large noncanonical translatome in yeast, showing most translated elements are not conserved genes and contribute to phenotype through fast-evolving mechanisms.