Angela M Yu

The paper develops COMPASS, a method to assess splicing variant effects across cell types, identifying disease-associated variants and cell type-specific splicing programs.

The paper identifies a nuclear RNA degradation code (NRDC) that recognizes transcripts with both a 5' splice site and a poly(A) junction, leading to their degradation and contributing to disease.

This study investigates how pseudoknot base pairing affects cotranscriptional structural switching in fluoride riboswitches, showing a critical wobble base pair is essential for function across different temperatures.

The paper identifies sequence-specific sensitivity to JTE-607 in mRNA 3' processing by analyzing over 260,000 sequence variants and developing a predictive model.

DUETT identifies RNA structural transitions from chemical probing data by using a feedback control-inspired method and linear regression to detect known and novel events.

The paper develops a statistical model to estimate RNA structure chemical probing reactivity using reverse transcriptase stops and mutations from a single experiment.