Author
University of California, IrvineORCID 0000-0002-1314-3452Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Lindsey V. Soles, Shuangyu Li, Liang Liu, Kristianna S.K. Sarkan, Erik Alvstad, Lusong Tian, Yoseop Yoon, Marielle Cárdenas Valdez, Ivan Marazzi, Yongsheng Shi
The paper shows that splicing and 3' processing compete to shape the human transcriptome, with splicing inhibition activating 3' processing and vice versa.
Genes & Development · Jul 1, 2026Peer-reviewedMolecular Biology
Lusong Tian, Liang Liu (50022), Yoseop Yoon, Lindsey V. Soles, Marielle Cárdenas Valdez, Joshua Jeong, Clinton Yu, Lan Huang, Yongsheng Shi
This study identifies LENG8 as a conserved RNA nuclear retention factor that prevents misprocessed mRNAs and noncoding RNAs from being exported, ensuring proper nuclear quality control.
Molecular Cell · Mar 19, 2026Peer-reviewedMolecular Biology
Lindsey V. Soles, Liang Liu, Xudong Zou, Yoseop Yoon, Shuangyu Li, Lusong Tian, Marielle Cárdenas Valdez, Angela M Yu, Hong Zhen Yin, Wei Li, Fangyuan Ding, Georg Seelig, Lei Li, Yongsheng Shi
The paper identifies a nuclear RNA degradation code (NRDC) that recognizes transcripts with both a 5' splice site and a poly(A) junction, leading to their degradation and contributing to disease.
Molecular Cell · Apr 1, 2025Peer-reviewedMolecular Biology
Liang Liu, Angela M Yu, Xiuye Wang, Lindsey V. Soles, Xueyi Teng, Yi-Ling Chen, Yoseop Yoon, Kristianna S.K. Sarkan, Marielle Cárdenas Valdez, Johannes Linder, Whitney England, Robert C. Spitale, Zhaoxia Yu, Ivan Marazzi, Feng Qiao, , Yongsheng Shi
The paper identifies sequence-specific sensitivity to JTE-607 in mRNA 3' processing by analyzing over 260,000 sequence variants and developing a predictive model.
Nature Structural & Molecular Biology · Dec 1, 2023Peer-reviewedMolecular Biology