Lorena Postiglione

The paper uses time-lapse imaging to analyze lineage topology and replication kinetics in human BMSC colonies, revealing synchronized cell cycles and regulatory factors linking non-dividing cells with proliferating cells.

The paper quantifies hereditary epigenetic regulation of cell-cycle exit in human bone marrow stromal cells using a novel entropy metric applied to clonal colony data.

Cheetah is a computational toolkit that integrates real-time microscopy analysis with cellular control algorithms, demonstrating improved segmentation accuracy over thresholding methods in bacterial and mammalian cells.

ChipSeg segments bacterial and mammalian cells in microfluidic devices using thresholding, enabling fluorescence quantification and cell tracking in time-lapse experiments.

The paper demonstrates real-time feedback control of a molecular titration motif in E. coli using microfluidics and validates the approach with in silico simulations.

The paper develops a dual-input system to dynamically regulate gene expression and protein stability in mouse embryonic stem cells, enabling precise control of protein levels and faster response times.

This study demonstrates automated control of pluripotency in mouse embryonic stem cells using microfluidics and feedback algorithms to regulate Rex1 expression.