Winston J. T. Tan

This study shows that knocking out alpha2 spectrin in postnatal outer hair cells leads to a dissociation of prestin's gating charge movement from electromotility and structural changes in the SSC and plasma membrane-SSC space.

This paper presents the single particle cryo-EM structure of prestin from gerbil at 4.0 Å resolution, revealing its dimeric architecture and structural features that challenge the extrinsic voltage sensor hypothesis.

This study shows that βV spectrin knockout mice have normal outer hair cell function but reduced auditory brainstem response amplitudes and fewer nerve fibers, indicating βV spectrin's role in neuronal structure rather than OHC function.