Dhasakumar S. Navaratnam

This study shows that prestin's conformational changes during electromechanical transduction resemble a transport transition in pendrin, with shared structural and functional properties.

The paper identifies proteomic and transcriptomic differences between ischemic stroke patients with atrial fibrillation and carotid atherosclerosis using integrated multi-omics analyses.

This study shows that knocking out alpha2 spectrin in postnatal outer hair cells leads to a dissociation of prestin's gating charge movement from electromotility and structural changes in the SSC and plasma membrane-SSC space.

This paper presents the single particle cryo-EM structure of prestin from gerbil at 4.0 Å resolution, revealing its dimeric architecture and structural features that challenge the extrinsic voltage sensor hypothesis.

This study shows that βV spectrin knockout mice have normal outer hair cell function but reduced auditory brainstem response amplitudes and fewer nerve fibers, indicating βV spectrin's role in neuronal structure rather than OHC function.

This study shows that the MOC efferent system couples bilateral spontaneous activity in the developing auditory system, and its absence reduces auditory sensitivity at hearing onset.