Eleanna Kara

This study shows lipid droplets promote alpha-synuclein phase separation, leading to mitochondrial toxicity and neurodegeneration in Parkinson's disease.

The paper identifies genes regulating alpha-synuclein homeostasis and shows their differential expression correlates with increased rare risk variant burden in Parkinson's disease.

The paper identifies 38 genes regulating a-synuclein cell-to-cell transfer using an siRNA screen and shows genetic overlap with Parkinson's disease.

This study uses protein-protein interaction networks and machine learning to stratify Hereditary Spastic Paraplegias based on molecular mechanisms and clinical presentations.