Tim Bartels

This study shows lipid droplets promote alpha-synuclein phase separation, leading to mitochondrial toxicity and neurodegeneration in Parkinson's disease.

This paper introduces ASA-PD, an imaging method to detect and map α-synuclein oligomers in Parkinson's disease brain tissue, revealing a specific subpopulation of nanoscale oligomers as an early hallmark of the disease.

The paper identifies genes regulating alpha-synuclein homeostasis and shows their differential expression correlates with increased rare risk variant burden in Parkinson's disease.

This paper develops an iPSC platform to rapidly generate alpha-synuclein inclusions and investigates their formation, subtypes, and molecular interactions.

The paper develops a bacterial N-terminal acetylation system using yeast NatB complex to acetylate -synuclein in E. coli.