Author

Nagendran Ramalingam

Brigham and Women's HospitalORCID 0000-0002-9459-3593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ulf DettmeriD· 5 shared Tim BartelsiD· 3 shared Arati TripathiiD· 2 shared Eleanna KaraiD· 2 shared Elena Eubanks· 2 shared Elyse Guadagno· 2 shared Aazam Vahdatshoar· 1 shared Abid OueslatiiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersNeuroscience

Ulf DettmerORCID

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5 papers

Recent·Most cited

WDR44 drives de novo α-synuclein aggregation at the lysosomal membrane and promotes neuronal dysfunction in Parkinson's Disease

Maxime Teixeira, Razan Sheta, Morgan Bérard, Christine Insinna, Anne‐Laure Mahul‐Mellier, Constantin V. L. Delmas, Eva Lepinay, Walid Idi, Alexandra Ricard, Esther del Cid‐Pellitero, Christine Trabolsi, Stéphane Gobeil, Marie‐Hélène Canron, Erwan Bézard, Alex Rajput, , Abid Oueslati

This study identifies WDR44 as a driver of de novo α-synuclein aggregation at the lysosomal membrane, linking early aggregation events to neuronal dysfunction in Parkinson's Disease.

bioRxiv · Apr 7, 2026 · PreprintNeuroscience

Lipid droplets promote the aberrant liquid-liquid phase separation of alpha-synuclein leading to impaired energy homeostasis

Jose Cevallos, Elena Eubanks, Sunghoo Jung, Yiming Huang, Elyse Guadagno, Neeharika Rao Suvvari, Aryan Doshi, Nitya Ravinutala, Alejandro M. Mosera, Nagendran Ramalingam, Arati Tripathi, Tim Bartels, Ulf Dettmer, Eleanna Kara

This study shows lipid droplets promote alpha-synuclein phase separation, leading to mitochondrial toxicity and neurodegeneration in Parkinson's disease.

bioRxiv · Nov 20, 2025 · PreprintNeuroscience

A Dual Assay to Compare Protein Levels and Toxicity of Alpha-Synuclein Variants: Acute Expression of Wild-Type versus S129A

Baoyi Li, Oren A. Levy, Nagendran Ramalingam, Ulf Dettmer

The paper develops an assay to compare protein levels and toxicity of alpha-synuclein variants, finding that the S129A mutant does not affect acute expression or toxicity.

bioRxiv · Sep 23, 2025 · PreprintCell Biology

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease

Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestanifarahani, Jinying Wang, Jordan Elliott, Nora S. Jaber, Fulya Akçimen, Sara Bandrés‐Ciga, Fadel Helweh, Jun Liu, Sanjana Archakam, Robert Kimelman, , Eleanna Kara

The paper identifies genes regulating alpha-synuclein homeostasis and shows their differential expression correlates with increased rare risk variant burden in Parkinson's disease.

Cell Reports · May 1, 2025Peer-reviewedCell Biology

Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of alpha-synuclein inclusions

Isabel Lam, Alain Ndayisaba, Amanda J. Lewis, YuHong Fu, Giselle T. Sagredo, Anastasia Kuzkina, Ludovica Zaccagnini, Meral Celikag, Jackson Sandoe, Ricardo L. Sanz, Aazam Vahdatshoar, Timothy D. Martin, Nader Morshed, Toru Ichihashi, Arati Tripathi, , Vikram Khurana

This paper develops an iPSC platform to rapidly generate alpha-synuclein inclusions and investigates their formation, subtypes, and molecular interactions.

Neuron · Jul 29, 2024Peer-reviewedNeuroscience