James E. Tomkins

This study investigates the functional consequences of catalytic activity loss in LRRK2, showing impaired proteostasis and altered interactome in guanosine nucleotide-depleted Lrrk2.

The paper identifies the Pgb1 locus as controlling glycogen aggregation in aged hippocampal astrocytes without affecting cognitive function.

This study identifies Apbb1ip as a genetic modulator of immune gene co-expression in aged mouse hippocampus, revealing age-related transcriptomic changes and immune response upregulation.

This study identifies genetic modifiers of LRRK2 mutations in Parkinson's disease, finding a significant variant in CORO1C and a polygenic risk score effect on penetrance.

This study uses protein-protein interaction networks and machine learning to stratify Hereditary Spastic Paraplegias based on molecular mechanisms and clinical presentations.

PINOT is a web tool that integrates and curates protein-protein interaction data from multiple sources to construct PPI networks for human and C. elegans.