Nikoleta Vavouraki

The paper shows that RpS12 induces the Xrp1short isoform in Rp+/- cells, which is necessary and sufficient for their elimination, challenging existing models of ribosomal protein-linked fitness surveillance.

The paper identifies CHEK1 and BIRC5 as therapeutic targets in ARID1A-deficient bladder cancer using patient-derived tumoroids and public datasets.

This study identifies SLITRK3 mutations in humans linked to epileptic encephalopathy and shows their loss-of-function effect in neurons and mice, highlighting a role in synapse development and neurological function.

The paper constructs tissue-specific LRRK2 interactomes and identifies a functional cluster within the striatum, highlighting distinct expression patterns and interactions in brain regions.

This study uses protein-protein interaction networks and machine learning to stratify Hereditary Spastic Paraplegias based on molecular mechanisms and clinical presentations.

PINOT is a web tool that integrates and curates protein-protein interaction data from multiple sources to construct PPI networks for human and C. elegans.