Nonequilibrium States Promote One-Pot Nonenzymatic Carbon Fixation in the Reverse Tricarboxylic Acid Cycle and Amino Acid Synthesis
Yu-Hsi Lin, Jian-Hau Peng, Shao‐Yu Huang…·Chieh-Chen Huang
The paper demonstrates that nonequilibrium conditions enable the nonenzymatic synthesis of glutamate from succinate and CO2 through the reverse tricarboxylic acid cycle under prebiotic conditions.