Sergio Poli

The paper uses single-cell transcriptomics to analyze an IPF cohort, revealing a transcriptional deficit refractory to current treatments and identifying STAT3 as a key regulator in the therapeutic gap.

The paper shows that inhibiting lactate transporters MCT1 and MCT4 reduces myofibroblast differentiation and pulmonary fibrosis in vitro and in vivo.

This study uses single-cell RNA-seq to identify aberrant cell populations in IPF lungs, revealing novel basaloid cells and vascular endothelial changes.

Across 1,176,683 airway and lung cells from 22 datasets, ACE2 rises with age, in males and in smokers' multiciliated cells, and is lowest in young children.