Author

David R. Ziehr

Brigham and Women's HospitalORCID 0000-0002-8029-7259Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Edy Yong KimiD· 2 shared Fei LiiD· 2 shared Matthew L. SteinhauseriD· 2 shared Niv VigderiD· 2 shared William M. OldhamiD· 2 shared Aseel H. Khalil· 1 shared Bradley A. MaroniD· 1 shared Ce GaoiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Edy Yong KimORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

TGF-β Coordinates Alanine Synthesis and Import for Myofibroblast Differentiation in Pulmonary Fibrosis

Fei Li, Niv Vigder, David R. Ziehr, Mari Kamiya, Hung N. Nguyen, Diana E. Ferreyra Faustino, Aseel H. Khalil, Hilaire C. Lam, Matthew L. Steinhauser, Edy Yong Kim, William M. Oldham

This study identifies alanine as a critical metabolite regulated by TGF-β that supports myofibroblast differentiation in pulmonary fibrosis through GPT2 and SLC38A2.

JCI Insight · Apr 23, 2026Peer-reviewedCell Biology

Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis

David R. Ziehr, Fei Li, K. Mark Parnell, Nathan M. Krah, Kevin J. Leahy, Christelle Guillermier, Ce Gao, Sean A. Prell, Niv Vigder, Sergio Poli, Jack Varon, Rebecca M. Baron, Bradley A. Maron, Nancy J. Philp, Lida P. Hariri, , William M. Oldham

The paper shows that inhibiting lactate transporters MCT1 and MCT4 reduces myofibroblast differentiation and pulmonary fibrosis in vitro and in vivo.

Science Translational Medicine · May 1, 2022Peer-reviewedCell Biology