Volker Sieber

This study characterizes GumG, an acetyltransferase involved in xanthan modification, revealing its substrate promiscuity and catalytic mechanism to enable engineered xanthan derivatives.

The paper screens 330 bacterial strains for c-di-GMP activated exopolysaccharides (EPS) using genetic modification and carbohydrate fingerprinting, identifying 10% as potential producers of novel EPS.

The paper introduces GRASP, a method for ancestral sequence reconstruction that handles large datasets and indels, demonstrating its ability to generate biologically active enzyme ancestors.

The paper develops a dCas12a-based tool for programmable gene activation and repression in prokaryotes, demonstrating its utility in metabolic engineering.