Jerrel L. Yakel

This study shows chronic diphenhydramine treatment fragments NREM2 sleep and degrades sleep quality in both 5XFAD Alzheimer's mice and wild-type mice.

The paper quantifies ACh/GABA co-transmitting neurons in the mouse brain using a combination of transgenic labeling, imaging, and machine learning.

The paper investigates how endemic viral infections alter the neuronal proteome and links these changes to neurodegenerative disease pathways.

This study shows that loss of GABA co-transmission from cholinergic neurons in mice leads to deficits in social, spatial, and fear memory, and altered behavior strategies.

The paper investigates how cholinergic activation of interneurons disinhibits CA1 pyramidal neurons, leading to synaptic plasticity in hippocampal excitatory synapses.