Author

Diane E. Youngstrom

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Assay:electronic health records· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Graham H. DieringiD· 2 shared Amita SehgaliD· 1 shared Ayland C. LetsingeriD· 1 shared Bumsik ChoiD· 1 shared Caitlin E. RandolphiD· 1 shared Camilo GuevaraiD· 1 shared Connor H. Beveridge· 1 shared Fabio Urbina· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Graham H. DieringORCID

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Author profile →

3 papers

Recent·Most cited

Diphenhydramine Disrupts Sleep Architecture in 5XFAD Alzheimers Disease Model and Wild-Type Mice

Margaret Hemphill Copeland, Diane E. Youngstrom, Kathryn S. Konrad, Graham H. Diering, Ayland C. Letsinger, Leslie R. Wilson, Jerrel L. Yakel, Jesse D. Cushman

This study shows chronic diphenhydramine treatment fragments NREM2 sleep and degrades sleep quality in both 5XFAD Alzheimer's mice and wild-type mice.

bioRxiv · Jul 27, 2026 · PreprintNeuroscience

Sleep-dependent clearance of brain lipids by peripheral blood cells

Bumsik Cho, Diane E. Youngstrom, Samantha L. Killiany, Camilo Guevara, Caitlin E. Randolph, Connor H. Beveridge, Pooja Saklani, Gaurav Chopra, Amita Sehgal

The paper shows that sleep in Drosophila allows peripheral hemocytes to clear lipids from the brain, and this process is mediated by the eater receptor.

Nature · Feb 11, 2026Peer-reviewedMolecular Biology

Coordinated regulation of CB1 cannabinoid receptors and anandamide metabolism stabilizes network activity during homeostatic scaling down

Michael Y. Ye, Sarah Monroe, Sean M. Gay, Michael Armstrong, Diane E. Youngstrom, Fabio Urbina, Stephanie L. Gupton, Nichole A. Reisdorph, Graham H. Diering

This study shows that chronic hyperexcitation in cultured neurons triggers homeostatic downscaling and enhances endocannabinoid signaling through coordinated changes in FAAH, anandamide, and CB1.

eNeuro · Oct 31, 2022Peer-reviewedNeuroscience