Ruben De Man

This study identifies early alveolar niche disruption and aberrant epithelial reprogramming in IPF using multi-modal analyses of patient cohorts.

The paper investigates age-related changes in proximal pulmonary artery mechanics in mouse models, finding increased stiffness and collagen reorientation linked to aging biomarkers and cellular senescence.

This study examines hypoxia-induced cardiopulmonary remodeling in mice, finding that pulmonary artery stiffening due to collagen remodeling precedes and correlates with cardiac and lung dysfunction, with partial recovery observed after normoxia.

The paper introduces Binary Cellular Analysis to quantify growth and development by modeling cell division and proliferation, providing equations for fetal growth and body part formation.

This study uses multi-omic data to identify age-related changes in lung cell composition and molecular programs associated with aging and senescence.

The paper introduces two new growth processes, UNI-GROWTH and ALLO-GROWTH, and their mathematical equations to model cellular development across species.