John E. McDonough

Single-nucleus multiomic and ex vivo lung slice profiling of human idiopathic pulmonary fibrosis identifies Alveolar Intermediate cells bridging alveolar and Aberrant Basaloid states and reveals AP-1 chromatin injury memory.

This study shows NUPR1 inhibition worsens oxidative stress, mitochondrial dysfunction, and metabolic imbalance in COPD, linking it to ferroptosis and disease progression.

This study investigates GPR87's role in pulmonary fibrosis, finding it highly expressed in IPF lungs and protective against fibrosis when knocked down in multiple models.

iDESC identifies differential expression in scRNA-seq data with multiple subjects by separating subject effects from disease effects, showing better performance than existing methods.

This study uses multi-omic data to identify age-related changes in lung cell composition and molecular programs associated with aging and senescence.