NeurosciencebioRxivPreprint
SynPull: a novel method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
Shekhar Kedia, Emre Fertan, Yunzhao Wu…·David Klenerman
SynPull combines single-molecule pulldown, super-resolution microscopy, and computational analysis to study protein aggregates in synaptosomes from human and mouse samples, revealing AT8-positive tau as the predominant aggregate in Alzheimer's disease.