John S. H. Danial

Simulating Multi-Colour Single-Molecule Localisation Microscopy Using an RGB Camera

This paper demonstrates that RGB cameras can effectively classify up to six fluorophores in SMLM with high precision, offering a cost-effective alternative to spectral imaging.

Super-resolution microscopy of nanoscopic alpha-synuclein aggregates in brain samples indicates a subset of cells have disrupted protein homeostasis prior to Lewy body formation in Parkinson's disease

The paper uses super-resolution microscopy and SIMOA to analyze alpha-synuclein aggregates in Parkinson's disease brain samples and mouse models, finding larger aggregates in PD samples and differences based on extraction methods.

SynPull: a novel method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy

SynPull combines single-molecule pulldown, super-resolution microscopy, and computational analysis to study protein aggregates in synaptosomes from human and mouse samples, revealing AT8-positive tau as the predominant aggregate in Alzheimer's disease.

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's Disease

This study shows that oligodendrocytes produce amyloid beta in Alzheimer's Disease and that suppressing this production improves brain pathology and neuronal function.

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease

The paper shows that apoE isoforms modulate Aβ aggregation, clearance, and toxicity in Alzheimer's disease, with implications for therapeutic strategies.