Lourdes López-Onieva

This study shows DGCR8 suppresses endogenous dsRNA from TEs to prevent IFN response activation, with implications for 22qDS.

This study identifies the ETS transcription factor pointed (pnt) as essential for germline survival in Drosophila, showing its role in regulating PGC proliferation and preventing apoptosis.

This study shows BMAL1 represses transposable elements in pluripotent cells independently of CLOCK, leading to genome-wide changes and totipotency features when BMAL1 is deleted.

The paper shows that Polycomb repression during S/G2 phases restricts differentiation gene activation, allowing it to occur primarily in G1 phase in mouse ESCs.

The paper shows that PRC2 subunits are differentially recruited across the cell cycle in mESCs, enabling chromatin state changes that facilitate differentiation in G1.