Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease
Yu‐En Lin, Chin-Hsien Lin, En-Peng Ho, Yi-Ci Ke, Stavroula Petridi, Christopher J. H. Elliott, Lee‐Yan Sheen, Cheng-Ting Chien
This study shows that Gastrodia elata Blume extract protects against LRRK2-G2019S Parkinson's disease by activating glial Nrf2 and inhibiting Mad/Smad signaling in both fly and mouse models.
eLife · Nov 15, 2021Peer-reviewedNeuroscience