Stavroula Petridi

The paper shows that tissue-wide metabolic buffering allows neural stem cells to maintain proliferation despite mitochondrial dysfunction, highlighting the role of tissue heterogeneity in resilience.

This study develops mRNA-LNP therapy for MNGIE, restoring nucleoside balance and TP expression in mice through subcutaneous delivery.

This study identifies Nup153's role in repressing neuronal genes through HDAC1-mediated epigenetic regulation, influencing chromatin states and neuronal responsiveness.

The paper uses single-molecule FISH to study mtDNA heteroplasmy dynamics in Drosophila and human cells, revealing developmental bottlenecks and selection effects on mutation load.

This study shows that Gastrodia elata Blume extract protects against LRRK2-G2019S Parkinson's disease by activating glial Nrf2 and inhibiting Mad/Smad signaling in both fly and mouse models.

The paper uses an in vivo electroretinogram screen in Drosophila to identify Rab10 as a strong LRRK2-G2019S substrate in dopaminergic neurons, distinguishing it from Rab3.

This study identifies Rab10 as a critical mediator of LRRK2-G2019S-induced neurodegeneration in specific dopaminergic neurons, showing rescue of visual and motor deficits but not sleep dysfunction.