Christopher J. H. Elliott

The paper identifies GEFs and GAPs modulating Rab10 phosphorylation and abundance by LRRK2-G2019S in neurons, showing Crag acts as a GEF and plx as a conventional GAP.

This study shows that Gastrodia elata Blume extract protects against LRRK2-G2019S Parkinson's disease by activating glial Nrf2 and inhibiting Mad/Smad signaling in both fly and mouse models.

This study investigates the differential roles of Rab10 in LRRK2-G2019S-induced behavioral deficits in Drosophila dopaminergic neurons, finding that Rab10 modulates specific phenotypes but not others.

This study shows that α-synuclein accumulation in presynaptic terminals causes synaptic dysfunction and progressive neurodegeneration in a Drosophila model, with similar findings in patient samples.

The paper investigates the role of Hsc70-5/mortalin loss in Drosophila Parkinson disease models and shows that autophagy inhibition rescues multiple phenotypes.

The paper uses an in vivo electroretinogram screen in Drosophila to identify Rab10 as a strong LRRK2-G2019S substrate in dopaminergic neurons, distinguishing it from Rab3.

This study identifies Rab10 as a critical mediator of LRRK2-G2019S-induced neurodegeneration in specific dopaminergic neurons, showing rescue of visual and motor deficits but not sleep dysfunction.

This paper identifies a shared visual processing dysfunction in Nhe3 mutant Drosophila and autistic humans, suggesting a genetic basis for autism-related sensory alterations.

This paper characterizes a Drosophila model of saposin deficiency, showing lysosomal storage, neurodegeneration, and calcium homeostasis defects similar to human LSDs.