Amber Baldwin

Alternative splicing switches human Musashi-2 between cytoplasmic and nuclear regulatory functions

This study identifies an alternative splicing event in MSI2 that determines its subcellular localization and regulatory function.

eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small molecules

The paper identifies eIF3d and eIF3e as mediators of hypoxia-induced translational control and shows that small molecules can inhibit this process.

Ribosome Profiling Reveals Translational Reprogramming via mTOR Activation in Omacetaxine Resistant Multiple Myeloma

This study identifies translational reprogramming via mTOR activation as a mechanism of omacetaxine resistance in multiple myeloma and suggests combination therapy with mTOR inhibitors.

Comparative analysis of 43 distinct RNA modifications by nanopore tRNA sequencing

This study demonstrates the use of updated nanopore sequencing to characterize 43 RNA modifications in tRNAs, including mitochondrial and viral tRNAs, and provides best practices for future research.

In situ spatial reconstruction of distinct normal and pathological cell populations within the human adrenal gland

This study uses spatial transcriptomics to analyze human adrenal tissue, supporting the centripetal differentiation model and characterizing aldosterone-producing micronodules.

Small molecule inhibition of multiple RNA binding proteins underlies Musashi-2 independent phenotypes

The paper identifies a small molecule inhibitor that targets multiple RNA binding proteins, showing its effects are independent of Musashi-2 and provides a framework for validating RBP inhibitor specificity.

RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells

The paper identifies RNA-binding proteins and RNA decay factors that regulate aldosterone production kinetics in steroidogenic cells through coordinated transcription and decay mechanisms.

A streamlined, cost-effective, and specific method to deplete transcripts for RNA-seq

The paper develops a cost-effective RNaseH-based method for rRNA depletion in RNA-seq, showing comparable or better performance than commercial kits.