OSTM1 is a ubiquitin E3 ligase that suppresses B-cell malignancy by activating the cAMP/PKA/CREB pathway
Muhammad Usama Tariq, Namratha Sheshadri, Jianliang Shen, Jaeyong Jung, Haowei Li, Kevin Lu, Junrong Yan, Mark C. Koch, Giuseppe Caso, Hassan Sajjad, Brinda Kizhakke Vallat, Stephen Kevin Burley, Yi Sun, Tong Liu, Hong Li A, , Wei Zong
This study identifies OSTM1 as a tumor suppressor in B-cell malignancies by showing it activates the cAMP/PKA/CREB pathway through ubiquitin E3 ligase activity.
bioRxiv · Sep 24, 2026 · PreprintCancer Biology