Shridar Ganesan

Monoallelic expression characterizes a distinct molecular and clinical group of breast tumors

The paper identifies a distinct breast tumor group with monoallelic gene expression linked to poor prognosis and develops a method to detect allelic imbalance.

RESPIRATION DEFECTS LIMIT SERINE SYNTHESIS REQUIRED FOR LUNG CANCER GROWTH AND SURVIVAL

This study shows that mitochondrial DNA mutations in NSCLC cause respiration defects, leading to glucose dependency, reduced serine synthesis, and increased cancer survival.

Immune Checkpoint Blockade Delays Cancer and Extends Survival in Murine DNA Polymerase Mutator Syndromes

This paper shows that immune checkpoint blockade (ICB) can delay cancer onset and improve survival in mice with mutator syndromes, but only if administered prophylactically before tumors develop.

Genomic Landscape of Lymphatic Malformations: A Case Series and Response to the PI3Kα Inhibitor Alpelisib in an N-of-One Clinical Trial

This paper reports the genomic profile of lymphatic malformations, identifies PIK3CA and NRAS mutations, and shows a response to the PI3K inhibitor alpelisib in a personalized trial.

Germline testing data validate inferences of mutational status for variants detected from tumor-only sequencing

This paper evaluates computational methods to infer germline vs. somatic variants from tumor-only sequencing data using 1,608 patients and compares results to germline testing.

All-FIT: Allele-Frequency-based Imputation of Tumor Purity from High-Depth Sequencing Data

All-FIT estimates tumor purity from high-depth sequencing data by analyzing allele frequencies, outperforming existing methods in simulated and clinical data.