Author

Namratha Sheshadri

Rutgers, The State University of New JerseyORCID 0000-0003-4912-7275Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Wei Zong· 2 shared Alexander J. ValvezaniD· 1 shared Brinda Kizhakke VallatiD· 1 shared Christian S. HinrichsiD· 1 shared Daniel HerranziD· 1 shared Emily Hyde· 1 shared Eric N. ChilesiD· 1 shared Francesco BertoniiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Wei Zong

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 24, 2026

OSTM1 is a ubiquitin E3 ligase that suppresses B-cell malignancy by activating the cAMP/PKA/CREB pathway

Muhammad Usama Tariq, Namratha Sheshadri, Jianliang Shen…·Wei Zong

This study identifies OSTM1 as a tumor suppressor in B-cell malignancies by showing it activates the cAMP/PKA/CREB pathway through ubiquitin E3 ligase activity.

DOI 10.64898/2026.01.23.701155

mouseexperimental assay

𝕏 PostBluesky

Cancer BiologybioRxivPreprintDec 24, 2025

PTEN-loss confers dependence on the guanylate synthesis enzyme IMPDH in T-cell acute lymphoblastic leukemia

Rayees Ahmad Padder, Thu Le Le, Emily Hyde…·Alexander J. Valvezan

This paper identifies IMPDH as a therapeutic target in PTEN-deficient T-ALL, showing IMPDH inhibitors selectively kill these cells and extend survival in mouse models.

DOI 10.64898/2025.12.22.696045

mouseexperimental assay

𝕏 PostBluesky