Adam J. Mulkern

This study identifies resistance determinants to antisense antibiotics by analyzing mutations in gram-negative pathogens exposed to CPP-PNA conjugates, revealing adaptation strategies and resistance mechanisms.

This study shows that combining DNA-damaging agents with antibiotics can reduce resistance evolution in specific hypermutator bacterial genotypes but not others.

This study shows that multidrug resistance plasmids face a trade-off between phage resistance and conjugative ability, which affects their evolutionary response to plasmid-dependent phages.