Alfredo J. Garcia

This study shows that fentanyl increases locus coeruleus bursts and transient breathing elevations, with divergent respiratory responses after repeated opioid use.

This study investigates fentanyl-induced diaphragmatic discoordination in mice, identifying two phases of respiratory dysfunction and showing that MOR antagonism reverses disordered diaphragm activity.

This study shows that noradrenergic modulation enhances inspiratory network synchrony via NMDAR activity, stabilizing respiratory rhythmogenesis in the preBotzinger complex.

This study shows that chronic fentanyl use alters microglia activity and amyloid beta clearance in Alzheimer's disease mice, potentially influencing disease progression.

The paper models how norepinephrine modulates preBotzinger complex neurons through two mechanisms, revealing parameter regimes where silent neurons remain inactive and explaining differential burst frequency and duration effects.

This study shows that neonatal intermittent hypoxia causes a pro-oxidant state and NMDA receptor imbalance, leading to long-term synaptic plasticity and memory deficits, which can be mitigated by early antioxidant treatment.

The paper investigates how HO-2 and CSE-derived H2S modulate hypoglossal motoneuron activity in mice, showing their role in upper airway control during sleep apnea.

This study shows that intermittent hypoxia increases HIF1a in wildtype mice, leading to oxidative stress, reduced NMDA receptors, and impaired LTP in the hippocampus, which contributes to memory deficits.