Darwin Chang

This study examines the molecular effects of indoor tanning by analyzing mutation patterns in melanocytes from tanning bed users and finds increased mutation burdens and distinct mutational signatures.

The paper develops software to infer copy number and detect single nucleotide variants in spatial transcriptomics data, applied to skin cancer to reveal genetic patterns and clonal populations.

This study genotypes individual melanocytes from human skin, revealing mutation patterns linked to sun exposure, skin cancer risk, and melanoma origins.