Tuyet M. Tan

This study examines the molecular effects of indoor tanning by analyzing mutation patterns in melanocytes from tanning bed users and finds increased mutation burdens and distinct mutational signatures.

The paper introduces Droplet Hi-C, a method for single-cell chromatin conformation profiling, and demonstrates its application in analyzing gene regulatory programs and detecting genetic variations in cancer cells.

This study genotypes individual melanocytes from human skin, revealing mutation patterns linked to sun exposure, skin cancer risk, and melanoma origins.