Author

Nicole Grbic

Boston UniversityORCID 0000-0001-5641-2934Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron Richard WaddelliD· 2 shared Kassidy LeibowitziD· 2 shared Marianne CollardiD· 2 shared Rhoda M. AlaniiD· 2 shared William Austin WyantiD· 2 shared Kihyun ParkiD· 1 shared Philip A. ColeiD· 1 shared Sabah ChoudhuryiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

Aaron Richard WaddellORCID

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2 papers

Recent·Most cited

p300 KAT regulates SOX10 stability and function in human melanoma

Aaron Richard Waddell, Nicole Grbic, Kassidy Leibowitz, William Austin Wyant, Sabah Choudhury, Kihyun Park, Marianne Collard, Philip A. Cole, Rhoda M. Alani

This study identifies p300 KAT as a regulator of SOX10 stability and function in melanoma, showing that inhibiting p300 reduces SOX10 levels and melanoma proliferation and invasion.

Cancer Research Communications · Jul 12, 2024Peer-reviewedCancer Biology

The p300 KAT inhibitor, A-485, inhibits melanogenesis and melanin content in human melanocytes

Nicole Grbic, Aaron Richard Waddell, Kassidy Leibowitz, William Austin Wyant, Marianne Collard, Rhoda M. Alani

This study shows that the p300 inhibitor A-485 reduces melanin production in human melanocytes by decreasing MITF and DCT expression.

bioRxiv · Feb 14, 2024 · PreprintCell Biology