Rhoda M. Alani

This study shows that corin, a CoREST inhibitor, reduces ATRT tumor growth, increases differentiation, and extends lifespan in xenograft models.

The paper shows that inhibiting the CoREST complex with corin alters RNA splicing, increases neoantigen expression, and enhances tumor immunity in melanoma.

This study identifies the LHC repressor complex as a therapeutic target in MPNST, showing that its inhibitor corin induces apoptosis and inhibits proliferation and invasion.

This study identifies p300 KAT as a regulator of SOX10 stability and function in melanoma, showing that inhibiting p300 reduces SOX10 levels and melanoma proliferation and invasion.

This study shows that the p300 inhibitor A-485 reduces melanin production in human melanocytes by decreasing MITF and DCT expression.