Lana Talmane

This study shows that genetic background and environmental factors determine the trajectory of cancer evolution in mice, with distinct mutational paths despite similar final tumor states.

The paper investigates how strand-asymmetric processes like replication and transcription influence DNA damage, repair, and mutagenesis, revealing mechanisms that shape cancer genome evolution.

The paper identifies mutational biases at germline regulatory sites, showing increased structural variants and insertions at transcription factor binding sites, with implications for evolution and disease.

The paper shows splicing enhances expression of AT-rich genes by increasing mRNA stability and cytoplasmic localization, while GC-rich genes are less affected by splicing.