Rosina Savisaar

Alternative splicing dynamics during human cardiac development in vivo and in vitro

This study maps alternative splicing dynamics during human cardiac development and identifies splicing markers in iPSC-derived cardiomyocytes, revealing both similarities and differences with native cardiac splicing patterns.

Phylogenetic relatedness rather than aquatic habitat fosters horizontal transfer of transposable elements in animals

The paper analyzes horizontal transfer of transposable elements in 247 animal species, finding that phylogenetic relatedness, not aquatic habitat, strongly influences HTT rates.

Computational prediction of human deep intronic variation

This study evaluates computational tools for predicting the functional impact of deep intronic variants, finding significant differences in performance and highlighting the trade-off between interpretability and predictive power.

Transcription and splicing dynamics during early Drosophila development

This study uses NET-seq to analyze co-transcriptional splicing dynamics in Drosophila embryos, revealing differences in splicing timing and intron definition across developmental stages.

Splicing buffers suboptimal codon usage in human cells

The paper shows splicing enhances expression of AT-rich genes by increasing mRNA stability and cytoplasmic localization, while GC-rich genes are less affected by splicing.