Author

Mark Rowland Hutchinson

ARC Centre for Nanoscale BioPhotonicsORCID 0000-0003-2154-5950Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Adam Añonuevo· 1 shared Adam J. Hirst· 1 shared Andrew B. DippeliD· 1 shared Andrew P. ShoubridgeiD· 1 shared Anita M. Mahadevan-JanseniD· 1 shared Bridget MilkyiD· 1 shared Carmen K. H. MakiD· 1 shared Cédric BardyiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperNeuroscience

Adam Añonuevo

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3 papers

Recent·Most cited

Enhancement of antibody thermostability and affinity by computational design in the absence of antigen

Mark Rowland Hutchinson, Jeffrey A. Ruffolo, Nantaporn Haskins, Michael J. Iannotti, Giuliana Vozza, Tony Pham, Nurjahan Mehzabeen, Harini Shandilya, Keith W. Rickert, Rebecca Croasdale-Wood, Melissa M. Damschroder, Ying Hui Fu, Andrew B. Dippel, Jeffrey J. Gray, Gilad Kaplan

This study uses DeepAb to design antibody variants with enhanced stability and affinity without antigen information, showing 91% and 94% improvements in thermal/colloidal stability and affinity, respectively.

mAbs · Jun 20, 2024Peer-reviewedMolecular Biology

Time course of lipopolysaccharide- and capsaicin-induced cytokine release in an ex vivo mouse model of vaginal inflammation

Jane Chalmers, Mark Rowland Hutchinson, Kelsi N. Dodds, Yuen Hei Kwok, Susan Evans, G. Lorimer Moseley

This study examines cytokine release in a mouse vaginal ex vivo model after LPS and capsaicin stimulation, finding increased IL-1β levels at 20 hours compared to 4 hours.

bioRxiv · Feb 11, 2023 · PreprintNeuroscience

BrainPhys neuronal medium optimized for imaging and optogenetics in vitro

Michael Zabolocki, Kasandra McCormack, Mark van den Hurk, Bridget Milky, Andrew P. Shoubridge, Robert Adams, Jenne Tran, Anita M. Mahadevan-Jansen, Philipp Reineck, Jacob Thomas, Mark Rowland Hutchinson, Carmen K. H. Mak, Adam Añonuevo, Leon H. Chew, Adam J. Hirst, , Cédric Bardy

The paper introduces BrainPhys Imaging, a medium optimized for live-cell imaging and optogenetics in human neuronal cultures, improving fluorescence signals and reducing phototoxicity.

Nature Communications · Nov 3, 2020Peer-reviewedNeuroscience